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Super UniGuide

Super UniGuide

Achieves higher cleavage efficiencies and allows editing of difficult targets.
Our improved guide RNA backbone offers increased cleavage efficiency, enabling efficient editing of virtually any target, including challenging ones. With a modified sequence and vast chemical modifications, it ensures consistently strong performance and works across all cell types. Supplied as a universal tracrRNA, it seamlessly pairs with crRNA from any gRNA supplier of your choice.
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Super UniGuide
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Key features

Enables editing of difficult targets

The improved tracrRNA sequence enhances CRISPR activity, allowing cleavage at challenging or previously uneditable targets.

Higher cleavage-driven editing efficiency

Delivers higher editing efficiency through improved cleavage, achieving up to 1000-fold with a mean increase of 7.4-fold across different targets.

Simple workflow integration

Used as a direct replacement for standard tracrRNA, requiring no protocol changes or additional optimization steps.

This kit is available for testing

Try our solutions in your lab and assess their impact on your editing outcomes. Early testers get hands-on access before launch and direct support from our team.

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Want to learn more about what we're building?

Whether you want to test, collaborate, or just ask a question—get in touch.

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Other products

Super UniGuide

Achieves higher cleavage efficiencies and allows editing of difficult targets.

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Super Knock-in Cocktail

Substance mix that transiently maximizes HDR efficiency and prevents off-target editing.

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Edit Selector Cocktail

Substance mix that enables selection and enrichment of edited cells.

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Prime Editing Cocktail

Molecule cocktail that increases prime editing efficiency and prevents unintended indels.

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CCBio Clonal Survivor Cocktail
Clonal Survival Cocktail

A combination of molecules that increases survival and outgrowth of cellular clones.

Coming soon

Join our Early Tester Program

As an early tester, you will receive product samples to use within your own research workflows, with no commitment beyond sharing your experience, which will directly inform the development of our tools.