Try our solutions in your lab and assess their impact on your editing outcomes. Early testers get hands-on access before launch and direct support from our team.
No. Our products are for research purposes only and are not approved for diagnostic or therapeutic applications.
The Super UniGuide works efficiently across all cell types. The Super Knock-in and Edit Selector Cocktail are currently optimized for human cells only. Mouse versions of both are in development and we expect them in a few months. Get in touch at crispr@clearcutbiolabs.com if you’d like to be notified when they’re ready for testing.
If you work in another species, we’d like to hear from you. We’re keen to extend these products beyond human and mouse, and knowing which organisms labs actually need helps us decide what to develop next.
All CCBio products work with RNP editing using Cas9, HiFi-Cas9 and Cas9 nickase (D10A). The Super Knock-in Cocktail and Edit Selector Cocktail also support Cas12a; the Super UniGuide is a tracrRNA and so does not apply to Cas12a.
Guides can be a crRNA:tracrRNA duplex or a fused sgRNA, delivered by electroporation or lipofection. The Super UniGuide is not compatible with sgRNA.
The Edit Selector Cocktail enriches the proportion of edited cells by performing a second Cas9 edit after any knock-in, base or prime edit that alters the gRNA recognition site.
Yes. All three can be used separately or together, depending on what’s limiting your experiment.
Achieves higher cleavage efficiencies and allows editing of difficult targets.
Substance mix that transiently maximizes HDR efficiency and prevents off-target editing.
Substance mix that enables selection and enrichment of edited cells.
Molecule cocktail that increases prime editing efficiency and prevents unintended indels.
A combination of molecules that increases survival and outgrowth of cellular clones.
Join our Early Tester Program
As an early tester, you will receive product samples to use within your own research workflows, with no commitment beyond sharing your experience, which will directly inform the development of our tools.